Ultra-Low Dose Naltrexone Attenuates Chronic Morphine-Induced Gliosis in Rats
نویسندگان
چکیده
منابع مشابه
Ultra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats
BACKGROUND The development of analgesic tolerance following chronic morphine administration can be a significant clinical problem. Preclinical studies demonstrate that chronic morphine administration induces spinal gliosis and that inhibition of gliosis prevents the development of analgesic tolerance to opioids. Many studies have also demonstrated that ultra-low doses of naltrexone inhibit the ...
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introduction: in the kindling-induced seizure model, low and repeated electrical or chemical stimulations, can elevate the neural network excitability and induce epileptiform seizures. opioid receptors are widely distributed in different areas of the brain. on the other hand, morphine has paradoxical effects and induces elevation or alleviation of the pain sensation and excitability, at differe...
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ژورنال
عنوان ژورنال: Molecular Pain
سال: 2010
ISSN: 1744-8069,1744-8069
DOI: 10.1186/1744-8069-6-22